The Prediction Predicament: Rethinking Necrotizing Soft Tissue Infections Mortality

Necrotizing Soft-Tissue Infections

151 Necrotizing soft-tissue infections have been recognized for centuries. Hippocrates vividly described the disease in the 5th century BC, as follows: ÒThe erysipelas would quickly spread in all directions. Flesh, sinews, and bones fell away in great quantities.Ó Necrotizing soft-tissue infections were subsequently designated as Òstreptococcal gangrene,Ó Òphagedena,Ó and Òphagedena gangrenosum...

Necrotizing Soft Tissue Infections.

Necrotizing Soft Tissue Infections

EVIDENCE DEFINITIONS · Class I: Prospective randomized controlled trial. · Class II: Prospective clinical study or retrospective analysis of reliable data. Includes observational, cohort, prevalence, or case control studies. · Class III: Retrospective study. Includes database or registry reviews, large series of case reports, expert opinion. · Technology assessment: A technology study which doe...

Necrotizing soft-tissue infections.

OBJECTIVE To provide a contemporary review of the diagnosis and management of necrotizing soft-tissue infections. DATA SOURCES Scientific literature and internet sources. STUDY SELECTION Major articles of importance in this area. CONCLUSIONS The mortality for necrotizing soft-tissue infections appears to be decreasing, possibly due to improved recognition and earlier delivery of more effe...

Necrotizing soft-tissue infections: clinical guidelines.

Options 1. Clindamycin should be considered in initial coverage for its effects on exotoxin production in group A beta-hemolytic Streptococcus (GAS) infections. 2. Vacuum-assisted closure devices may be helpful in secondary wound management after debridement of NSTIs. 3. Empiric vancomycin may be warranted during pending culture results to cover for the increasing incidence of community-acquire...